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<div class="pagetitle">Links & Resources</div>

<div class="text">
    <h3>Additional Systems Biology Program Contracts</h3>
    <div class="links">
        <h5><a href="http://www.sysbep.org/" target="_blank">Systems Biology of EnteroPathogens</a></h5>
        <h5><a href="https://www.systemsvirology.org" target="_blank">Systems Virology</a></h5>
        <h5><a href="http://www.broadinstitute.org/annotation/tbsysbio" target="_blank">TB Systems Biology</a></h5>
    </div>

    <h3>Systems Biology Working Group Program Meetings</h3>
    <div class="links">
        <h5><a href="http://www.niaid.nih.gov/LabsAndResources/resources/sb/Pages/sbwg.aspx" target="_blank">Panel of Advisers</a></h5>
        <h5><a href="https://www.systemsvirology.org/sbwg/index.html" target="_blank">2009 Meeting</a></h5>
        <h5><a href="http://www.broadinstitute.org/annotation/tbsysbio/1492.html" target="_blank">2010 Meeting</a></h5>
        <h5><a href="http://www.systemsinfluenza.org/SBWG2011/agenda.html" target="_blank">2011 Meeting</a></h5>
    </div>

    <h3>Resources</h3>
    <div class="links">
        <h5><a href="http://www.fludb.org" target="_blank">Influenza Research Database (IRD)</a></h5>
        <h5><a href="http://www.systemsbiology.org/isb-resources" target="_blank">Data Analysis, Visualization, and Workflow Tools</a></h5>
        <h5><a href="http://en.wikipedia.org/wiki/Influenza" target="_blank">Influenza Basics</a></h5>
        <h5><a href="http://www.niaid.nih.gov/topics/flu/Pages/default.aspx" target="_blank">NIAID's Role in Influenza Research</a></h5>
        <h5><a href="http://www.niaid.nih.gov/topics/flu/research/vaccineresearch/Pages/default.aspx" target="_blank">Vaccine Research Efforts at NIAID</a></h5>
        <h5><a href="http://www.cdc.gov/flu/" target="_blank">CDC Flu Page</a></h5>
        <h5><a href="http://www.who.int/topics/influenza/en/" target="_blank">WHO Flu Page</a></h5>
    </div>

    <h3>Core Capabilities</h3>

    <h4>Genomics Core</h4>
    <div class="subtitle">The genomics core provides a variety of services and support for researchers doing RNA expression, transcription factor binding, and other assays utilizing microarray technologies.</div>

    <h5>Capabilities</h5>
    <ul>
        <li>RNA QC via Bioanlayzer</li>
        <li>RNA labeling</li>
        <li>Hybridization/Washing</li>
        <li>Scanning</li>
        <li>Image Analysis</li>
    </ul>

    <h5>Platforms supported</h5>
    <ul>
        <li>Affymetrix</li>
        <li>Agilent</li>
        <li>Custom spotted</li>
        <li>Exiqon<br>
        </li>
    </ul>

    <h5>Common applications</h5>
    <ul>
        <li>mRNA expression</li>
        <li>microRNA expression</li>
        <li>ChIP-chip and ChIP-Seq</li>
    </ul>

    <h4>Proteomics Core</h4>
    <div class="subtitle">ISB's proteomics core is a full service facility specializing in peptide and protein identification via LC-MS/MS.</div>

    <h5>Instrumentation and Services</h5>
    <ul>
        <li>RNA QC via Bioanlayzer</li>
        <li>RNA labeling</li>
        <li>Hybridization/Washing</li>
        <li>Scanning</li>
        <li>Image Analysis</li>
    </ul>

    <h5>Autosamplers</h5>
    <ul>
        <li>Dionex FAMOS micro-autosamplers</li>
        <li>Agilent 1100</li>
    </ul>

    <h5>HPLC pumps</h5>
    <ul>
        <li>Agilent binary and quaternary microflow HPLC pumps</li>
        <li>Agilent quaternary nanoflow HPLC pump</li>
    </ul>

    <h5>Mass Spectrometers</h5>
    <ul>
        <li>Thermo Finnigan LCQ-DECA 3D ion-trap MS</li>
        <li>Thermo Finnigan LTQ linear ion-trap MS</li>
        <li>Applied Biosystems/Sciex Qstar Pulsar I Q-TOF MS</li>
        <li>Waters/Micromass Q-TOF Ultima API MS</li>
    </ul>

    <h5>Sample preparation and fractionation for LC-MS/MS including</h5>
    <ul>
        <li>a. sample (protein) precipitation, resolubilization, and digestion;</li>
        <li>b. sample cleanup (e.g. by off-line reverse-phase method);</li>
        <li>c. isotopic labeling by ICAT™ or iTRAQ™ for relative quantitation of proteins in complex samples;</li>
        <li>d. off-line strong cation exchange fractionation.</li>
    </ul>

    <h5>High-throughput LC-MS/MS</h5>
    <div class="subtitle">
        Data analysis via ISB proteomics data analysis pipeline: Sequest &gt; Peptide Prophet &gt; Protein Prophet &gt; SBEAMS (Systems Biology Experiment Analysis Management System).
    </div>
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